The Foot-LITE system has undergone simulator trials fully instrumented vehicle trials and a three vehicle prototype trial; the final field trial will be carried out on a thirty vehicle test fleet.
In addition, although Time-to-Line consideredtoC) is considered to be a useful indicator in driving simulator trials, it is often difficult to measure it in real traffic conditions without a specially equipped research vehicle [41].
In order to accommodate the acceptance or rejection of the research hypotheses of the previous section for a semi-dynamic driving simulator, experimental trials were planned aiming to gather driving performance data from the drivers while driving in the driving simulator and on-the-road.
Simulations were performed in Trial Simulator (v.2.2.1, Pharsight, Cary, NC).
After the processing of the results, the comparative analysis of the data collected from the trials in the driving simulator and the trials in the real traffic conditions followed.
11 Sample size was calculated using IcebergSim software version beta 4.0.3 (Practihc Coordinating Office, Oslo, Norway), a clinical trial simulator using a Monte Carlo model with 5000 simulations.
Sample size was calculated using the IcebergSim software version β 4.0.3 (Practihc Coordinating Office, Oslo, Norway), a clinical trial simulator using a Monte Carlo model with 5000 simulations.
Models of interest were implemented in the trial simulator TS2 version 2.1.2 (Pharsight, Mountain View, CA).
To check that randomisation had been successful, the control group were trained in the simulator after the trial.
For the population pharmacokinetic analysis, data file preparation was performed with SAS Version 8.2 and S-PLUS v. 6.0 for Trial Simulator (Insightful Corporation, Seattle, WA, USA); non-linear mixed effects modeling was performed with NONMEM version 5.11 (GoboMax, Hanover, MD, USA), run under Visual-NM Version 5.1 (RDPP, Montpellier, France).
