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According to recent studies, a stratospheric aerosol cloud of the size indicated by our CI simulations would have induced a cooling effect of ~6 9 °C in eastern Europe and Northern Asia, 2 4 °C in Western Europe26, and ~1 2 °C globally50, with an e-folding decay time of approximately 1 year51.
If maintenance cost fully determined the equilibrium value of the proboscis length, X moths in the first set of simulations would have the same proboscis length as Y moths in the second set.
In contrast to our results, lactate were less efficient during the experimental setting as our simulations would have suggested.
Had we chosen to use a different model of selection, we would then have tested somewhat different selection coefficients to map to the same range of fixation probabilities, but the results of the simulations would have been identical.
A plausible poor adherence scenario that would have been included in these simulations would have had 3 drug holidays and 25 missed doses over the 150 treatment day period.
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While using of zero equation model, the simulation would have great difference from the actual test.
A vast number of experiments would be necessary to study all interactions between these parameters and a 3D FEM simulation would have limitations in the computing time.
As shown from the graph, varying the damage factor used for the simulation would have little or no effect on the outcome of the simulation.
Points of simulations could have been chosen from structured method or Latin Hypercube method [15] which is a generalization of the Latin-Square design, however more points of simulation would have been needed.
One alternative to simulation would have been to compare to microarray estimates, as has been done to validate RNA-Seq technology in general (Marioni et al., 2008; Mortazavi et al., 2008).
We evaluated, for t-scores ranging from 4.5 to 8.5 (0.25 step-size) and with cluster sizes ranging from 1 to 15 (1-connection step-size) whether the simulation would have yielded any significant connections.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com