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To gain more insight into this issue, further work involving much longer simulations would be needed.
Literature guided, exploratory simulations would be needed to identify candidate details.
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The savings are ever more noticeable in the case of higher Péclet numbers, when larger physical times are needed to reach the asymptotic regime and thus, equivalently, much larger computational domain and simulation time would be needed in a traditional setup.
Our study allowed us to analyse the effectiveness of a vaccination strategy, whereas clinical trials with such an objective would have to be very large (i.e., for simulation, 169 departments per arm would be needed) [ 7].
For deciding on the superiority of a certain method, a simulation study in which true predictors and noise variables are assigned would be needed.
All simulations were carried out in implicit solvent, given the high box dimensions that would be needed for such elongated structures.
In the simulations, the unusual torsions convert to the nearest-conformational family, while longer timescales would be needed to appropriately relax these distorted regions.
Indeed, molecular dynamics simulations have indicated that considerable work is needed to achieve the degree of decrystallization that would be needed for enzymes to gain access to single cellulose chains [ 26, 76].
In simulation studies, Nguyen and Eisman estimated that 50 SNPs with odds ratios of 1.3 1.5 would be needed to provide a significant increase in reclassification.
Additional geophysical observations and research would be needed to reveal hydrological structure within Mt. Tokachidake and to run more realistic simulations in the future.
Thermal activation would be needed to complete this process.
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