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The numerical model used for the simulations was based on efficient advanced approximations for both spatial and temporal discretizations.
The upscaling procedure used in the forward simulations was based on the homogeneity-pattern created by thresholding the model space using the wavelet sensitivity matrix.
The algorithm to describe fibre positions for use in biomechanical simulations was based on the original description by Van der Helm et al. [20] A point cloud, generally consisting of more than 2000 points representing each marked muscle fibre, was sorted in, or according to the dominant anatomical direction of the fibre path.
The choice of selection coefficients in the SelSim simulations was based on previously reported estimates.
The first set of simulations was based on the MIST2 trial.
The cubic Lagrange hexahedral mesh used for the simulations was based on the end-systolic frame of the data (Wang et al. 2009) and was composed of 72 elements, with two elements transmurally.
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First, the simulations were based on one data set of PRO measures administered to CKD patients.
All simulations were based on simulated sibling pairs only, and the simulated marker was assumed to be the actual QTL.
It boils down to the details of the assumptions the simulations are based on.
Simulations are based on 5000 runs.
All simulations are based on OpenFOAM 1.7.1.
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