To this end, we have made five of the six models (the exception is the spatial model of D. melanogaster) available in Systems Biology Markup Language (SBML [ 32]) format, allowing for their simulation in multiple software tools, including AMIGO [ 33] and COPASI [ 34].
The convergence behavior and numerical stability of the proposed online algorithm are evaluated by computational simulations in two multiple-input and multiple-output models that represent a fourth order RLC circuit with two input voltages and two controllable voltage levels, and a doubly-fed induction generator with six inputs and six outputs for wind energy conversion systems.
Therefore, the self-bending behavior of the planar hydrogel bilayer was confirmed by experiments and simulations in which multiple values were assigned for each of the primary design parameters in origami-based engineering.
Simulation results in multiple heterogeneous 3D architectures demonstrate that our approach in generally can result in a 49.96% improvement in average delay, a 62.28% decrease in the reflection coefficient, and the optimization for delay can be more effective for higher non-uniform inter-plane interconnects.
Each simulation consisted in multiple generations, each generation corresponding to one week, enough for the model to reach steady-state between metabolism and diffusion of species between two generations.
Minimization, equilibration, and steered molecular dynamics (SMD) simulations were performed in multiple steps using NAMD2.7, the CHARMM27 force field for proteins with the CMAP correction, full electrostatics, and 2 fs time steps with hydrogen bonds constrained.
Important new features of this model include: (i) the simulation of AR in multiple tissue compartments (i.e., brain, liver, and gonad); (ii) AR binding and its effects upon the HPG axis; and (iii) free androgen effects on brain AR concentration.
Perhaps the most intriguing reveal though was Steep a sort of open-world winter sports simulation in which multiple players inhabit the same stretch of mountainous scenery skiing, wingsuiting, paragliding and/or snowboarding their way to the bottom – or to the nearest casualty department.
For categorical variables, if the χ condition was met, multiple group comparisons were performed by χ test; if not, Monte Carlo simulation was used in multiple group comparisons and the Fisher exact test was used to compare 2 groups.
We suggest that measures such as those presented here could be used to examine the convergence of biomolecular simulations in cases where multiple states may be present.
