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The first column ("Simulated") corresponds to the results of knockdown simulations for the initial logical model, while the last column ("Improved rules") displays the results obtained with the revised model (improved logical rules for Cyclin D1 as shown in Table 1).
We did not run simulations for the initial cell population size of 5000 as this would entail final cell counts of almost 30000.
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The modeling approach incorporates atomistic modeling, by virtue of molecular dynamics (MD) simulation, for simulating the initial unstrained equilibrium state, and equivalent-continuum modeling (ECM), by way of finite element approximations (FEA), for modeling the subsequent static/dynamic behaviors.
The validity and accuracy of the macroscopic model is successfully checked through the comparison with direct numerical simulations of the initial microscale model for amperometry tests.
Parallel simulation runs for the initial sample are used to construct a Kriging metamodel.
Considering a pair of two simulation cases for the initial conditions brings a good reliability of the analysis.
A simulation trace for the initial state { A(1), A(2), A(3), A(4)} is depicted on the left-hand-side of Figure 2.
In order to avoid using an uncertain model for volumetric simulation, the initial model is resampled and post-processed for uncertainty reduction.
This section documents results of a vascular tumour growth simulation for which the initial vascular geometry was taken from multiphoton fluorescence microscopy.
This is shown for the Brutus simulations, for the four different initial conditions.
As in the preceding simulations for the cubic anisotropy, the initial ((t=0)) circular precipitate, marked with a red dashed line, is placed in the center of the simulation domain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com