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The atmospheric and surface initialisation data are identical for all simulations and all start with same 3D ozone and wind fields.

Plasmode simulations and all analyses of real and plasmode datasets were performed on SAS 9.1.

We performed an initial run with 50 000 simulations and all loci, using the mean neutral FST as a preliminary value.

An overall conservative estimate t.95 is chosen to exceed the corresponding maximum for all simulations and all cancer sites investigated.

For all simulations and all cancer sites (Additional File 1, Tables S1, S2 and S3) the 95th percentile of the fitted gamma distributions and the 95th percentile of the simulated itself are all below 10.

That is to ask "how many simulated outbreaks result in secondary spread?" When all scenarios and all simulation results are considered together, infection spread beyond the seed premises in approximately 15% of the simulations run (mean value over all simulations and all scenarios).

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However, since this population was fully derived via simulation and all parameters were known, we were able to simulate the population without selection to define significance thresholds.

SH and W-SL formulated the optimization algorithms, SH performed simulation, and all authors contributed to the interpretation of the results and writing of the manuscript.

During the night following the ceremony, the serum induces a simulation and all of the Dauntless become sleep-walking soldiers ordered to attack the Abnegation compound.

We extracted 2500 structures from each MD simulation and all of these structures were used in the calculations described below unless otherwise stated.

The recorded simulation observations (Fig. 2b) show a more simplified network; however, there were fewer participants in these simulations and not all roles from the interviews were represented.

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