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Simulation studies from the present study show that this proposed approach would shorten trial durations without the low-performing of the trial design in comparison to existing approaches.
It was not until the drug agency reviewed driving simulation studies from controlled trials of the drug Intermezzo, which was approved in 2011 for middle-of-the-night waking, that a more complete picture of the risks emerged.
The algorithm was tested through simulation studies from which the minimum heritability and sample size for reasonable estimates of each parameter are determined.
Moreover, recent simulation studies from Möhring et al. [ 38] showed that designs including rows and columns outperformed one-dimensional blocking.
Our results and recommendations are based on extensive simulation studies from data which are generated from normal distributions.
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In a recent simulation study from our group, similar results were found [11].
Following approval from the Curtin Human Research Ethics Committee (No: RD-11 13), RD-11 13practising in six Australian states and territories were invited to participate in this simulation study, from June 20102to September 2013, via three channels.
This higher genome coverage might have also contributed slightly to improve accuracy estimates as expected from simulation studies for similar population sizes [ 4].
The initial structure used for these simulation studies was from the previously established homology model of GLUT4 [36].
Results from simulation studies were investigated, from which an appropriate sample size is determined for a cancer trait with a particular heritability.
The pilot simulation study has data generated from models A to E in Figure 2. We conducted 10 simulation studies, generating data from the five models described above under sample sizes 112 (the size of our real data example) and 1000.
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