Sentence examples for simulation regimen from inspiring English sources

Five simulated years of observed, monotonic improvement in disease state is approximately the "sweet spot" for pre-publication replication requirements in this particular simulation regimen.

By using the same PK model obtained with a TBW-based regimen, simulations of individual PK profiles were performed to assess the effect of IBW- and DW-based regimens on peak and Cmin concentrations.

The presence of the β-lactamase did not alter the concentrations of cefditoren (TEM-1 β-lactamase resistant) but highly modified those of amoxicillin over the entire dosing interval in amoxicillin tid regimen simulations, and in a lesser extent (from 4 h on) in amoxicillin/clavulanic acid tid regimen simulations.

Simulations for a regimen of 400 mg q4w show sustained reductions in LDLc without significant rebound in LDLc whereas a q8w schedule is predicted to require the higher dose of 800 mg to limit LDLc fluctuations.

For the 100 mg m−2 tri-weekly regimen, simulations predicted a nadir at day 7 post-Doc and recovery to baseline at ca. day 20 post-Doc, in patients whose baseline count was ca. 4250 neutrophils per μl.

PD models can test alternative dose regimens through simulation, allowing for informed assessment of potential dose regimens and study designs.

CI: confidence interval; DES: discrete event simulation; ERR: experimental remuneration regimen; FHU: family health unit; GP: general practitioner; NHS: National Health Service; PHCC: primary health care centre; PI: performance indicator.

Simulation with a standard regimen (15 mg/kg) of amikacin resulted in insufficient peak concentrations in >90% of patients, confirming the need to increase amikacin doses to ensure that adequate peak levels are achieved in sepsis patients.

In silico simulation of optimal treatment regimens may allow optimization of experimental and, later, treatment parameters.

Each regimen's simulation-derived PTA is multiplied by the percentage of isolates found at each MIC dilution; the sum of these products is the CFR[ 8].

42 The advantage of this approach, over testing competing dosing regimens by simulation, is that once the optimal target is defined, the optimal dose needed to reach that target is determined in a single step.