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A difficulty with process models is that they are based on the state of knowledge and simulation objectives defined at the time of their formulation.
Use of a similar fine-grained representation of bond dissociation may have yielded more precise simulation results, but that level of resolution and precision was not needed to meet the simulation objectives in Table 1.
1, 2 Similarly, modeling and simulation objectives are focused on recommending doses that are adequately demonstrated to be similar to those established in adults (an equivalence approach) or those which allow mapping of the exposure response relationship to suspected target activity thresholds.
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A single model function evaluation is the cycle of the decision variable selection, process simulation, model objective function evaluation and constraint evaluation of a candidate design.
The simulation results from the second and third methods contained some inaccuracy, but depending on the simulation objective, their simulation results may be acceptable.
This approach requires the numerical approximations for the flow (i.e. primal) problem and the adjoint (i.e. dual) problem which corresponds to a particular simulation objective output of interest.
After giving an overview of solution techniques for HVAC system simulation, the paper provides suggestions on how one should select an HVAC modeling approach relative to the simulation objective at hand.
We particularly stress the need for better documentation of the underlying assumptions of the modules on simulated processes and on the criteria applied in the selection of these modules for a particular simulation objective.
The simulation objective is to maximize glucose secretion.
The simulation objective function is to maximize the uptake of the amino acid being tested.
Because of the presence of equivalent alternative optima in constraint based-simulations of metabolism [ 18], many reactions may theoretically be able to carry a wide range of flux for a given simulation objective.
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