In this article, the research design, details of the simulation protocol, informatics issues, and the organization of the results into a web-accessible database are described.
Overall, the DoD's publicly available research portfolio indicates at least thirty different interdisciplinary socio-cultural research and development projects [17], many of which involve computational modeling, simulation, and informatics [17 21].
Participatory modeling is a methodology that leverages the principles of user-oriented design to ensure that computational applications, including modeling, simulation, and informatics technologies, are comprehensible to stakeholders in a decision space.
As a result, a number of national security thought leaders have suggested that new computational science techniques, including a wide range of modeling, simulation, and informatics approaches, might give decision-makers a jump on complex, seemingly intractable sociopolitical trends.
In a previous article (Beveridge et al. 2004. Biophysical Journal. 87 3799 3813), the research design, details of the simulation protocol, and informatics issues were described.
Yet within the national security community, most modeling, simulation, and other informatics projects follow an "over the fence" development model: researchers develop and demonstrate working systems in a research setting; the resulting systems are then thrown "over the fence" to the users who are presumably waiting to receive them.
While that type of informatic simulation of metagenomic reads is a useful approach for benchmarking different binning methods, the models used for such simulations simply can not capture all factors affecting read sampling from a real metagenome sequencing experiment.
The second is to marry his brain simulation with a medical informatics platform and suck up all the available data on mental diseases from public hospitals and the proprietary databases of pharmaceutical companies.
Paying attention to context is critical to establish a viable niche for informatics, modeling, and simulation as methodological species that add diversity and strength to the constantly evolving ecology of national security.
