Sentence examples for simulation dose from inspiring English sources

The structural model applied for the simulation (dose: 20 mg) was a linear two-compartment with first-order absorption and elimination.

DOI: http://dx.doi.org/10.7554/eLife.08931.019 To illustrate further the relationship between stimulus area and percentage of active cells, we plotted for each simulation dose the minimum duration needed to achieve 10%, 50%, and 90% activation.

In comparison, in a simulation dosing simvastatin at time of peak IL-6 concentration (6 hours), the predicted AUC ratio was only 1.1-fold.

Based on pharmacokinetic modelling and simulation, doses of 10 mg/kg for patients weighing less than 30 kg achieved tocilizumab exposure comparable to that of 8 mg/kg for patients weighing 30 kg or more.

For the simulations, doses of IFNβ-1b as well as corticosteroids were kept constant and their frequencies of administration were altered, and their effect on the accumulated CELs was simulated for a five-year (60 months) therapy period.

The performance of this amalgamation of methodology is investigated via the simulation of dose finding studies.

The predictions helped set expectations for the outcomes of phase II results, including optimal dosing regimens, and increased confidence in simulations and dose recommendations obtained with a nonlinear mixed-effects population PKPD model (N.R. Budha et al., unpublished data).

Based on the simulation, SC dosing of 30 mg/kg DCU nanosuspension once a day (s.i.d).i.d

To verify the simulation parameters, doses along the transverse axis of a Model 200 103Pd interstitial seed were calculated and compared to those calculated by the TG43 method.

For model-based simulations, the dose amount of 7,800 IU was chosen based on the mean weight (78 kg).

Although canakinumab appeared to improve clinical scores, based on our simulations, increasing dose levels beyond 150 mg (up to 900 mg) failed to further improve outcomes.