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The case study is used to demonstrate the potential of using the clinical simulation approach described in the paper.
For all the simulations, the values of threshold λ are chosen by the computer simulation approach described previously, and 1,000 Monte Carlo runs are carried out to estimate the value of λ.
The simulation approach described here combines a one-dimensional modelling of a RED stack with a fully three-dimensional finite volume modelling of the electrolyte channels, either planar or equipped with different spacers or profiled membranes.
We have explored plausible mechanisms using a computer simulation approach (described in detail in the Supplemental Material S1).
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Bonds and bond angles were held stationary during the simulation using the approach described by Andersen.[22] Apart from the surface hydroxyl groups, mineral phase atom positions were kept fixed during the simulations.
We based our simulations on the approach described by Mandl et al[ 18].
In addition our modeling and simulation approach is described, which has been done based on the ADAMS™ simulator.
First, the structural modelling of these objects and the required steps to obtain an adequate simulation approach are described.
Next, the simulation approach is described, results are presented, and a discussion and limitations of the simulation are given.
An integrated fluorescence microscopy simulation tool, similar to the approach described by Gardner et al., was recently integrated into cellPACK to enable cellPACK models to be compared more directly to microscope images and to begin to test competing hypotheses for distribution of the Env glycoprotein in immature HIV-1 virions.
For the comparison of GS with selection based on traditional BLUP-EBV estimated from phenotypic information, deterministic simulations were performed with SelAction, using the approach described above.
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