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The computer simulation allows a finer grain study than clinical data does.
The present simulation allows a detailed analysis of the effects of the intracellular properties on the reaction rates.
Although this simulation allows a substantial role for the health promotion program in reducing cardiovascular events, risk reduction with traditional antihypertensive medications is superior.
Although the duplicated protein sequences were ~500 amino acid long on average, our use of the much longer sequences for simulation allows a very stringent estimation of the false positive rate.
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Results: The proposed simulation allows an interactive or automated switching for regions or species of interest in the cell.
First, many of the general tradeoffs of the two problems are studied through simulation, allowing a wide coverage of algorithms and parameter values.
In addition, the numerical simulation allowed a thorough examination of the lateral deflection of the MSE wall, the lateral earth pressure on the MSE wall, and the maximum geogrid tension.
In contrast, an approach based on combining numerical optimisation methods with computational simulation allowed a sequence of tidal volume reductions to be computed for each virtual patient that maintained PaCO2 levels while significantly reducing peak airway pressures and dynamic alveolar strain in all patients.
Simulation results demonstrate that molecule distributions, reaction rate parameters, and structural parameters can be adjusted separately in the simulation allowing a comprehensive study of individual effects in the context of realistic cell environments.
Using as starting point the parameters-set obtained in [ 42, 51] as base value, we discuss how does input perturbation and stochastic simulation allow a model-based robustness analysis of a model that leads to multiple circuits.
Molecule distributions, reaction rate constants and structural parameters can be adjusted separately in the simulation allowing a comprehensive study of individual effects in the context of a realistic cell environment.
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