This conclusion inspired us to simulate administration first of the glucose competitor followed by chemotherapy.
Tumour cord drug response was evaluated by simulating the administration of eight biweekly cycles of paclitaxel.
(This is to avoid modelling an ever-increasing circulatory volume. Removal of volume simulates administration of haemostatic agent during ongoing bleeding; however, the model makes no assumptions regarding bleeding rate).
A computer screen-based simulator has been developed to simulate the administration of intravenous and analgesic drugs.
The individual net values of the area under the curve of plasma concentration (AUC) and cumulative urinary excretion (CUE), both obtained with the test formulation as post-dose minus baseline, were multiplied by 2, 3, 4, 5 and 6 and added to the baseline in order to simulate the administration of increasing single doses of the test, assuming dose linear kinetics.
As elderly patients traditionally experience a reduction in blood pHe due to nephron death, we simulate bicarbonate administration in a human with impaired renal function.
Particularly interesting is the increase of SASF observed when downregulation GKr, which simulates the administration of class III antiarrhythmic agents and is likely sustained by an increase in ICaL.
The difference in liver BA area under the curves (AUCs) over the course of simulated drug administration in the presence and absence of the theoretical inhibitor is given in Table 1.
Three-round MDA campaigns were simulated with administration of AL, AL + PQ, DP, and DP + PQ according to the schedule described above for coverage between 50% and 100% and EIRs between 1 and 50 for each drug and coverage level.
We simulated two administrations of aflibercept at a dosage of 3 mg/kg, and the predicted concentration profiles for free and bound aflibercept in all three compartments are shown in Figure 4. Similar results are predicted for other doses; therefore, we only present predictions for a single, intermediate dose.
