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Each simulated study was assessed for a QT-prolongation of regulatory concern using a concentration-effect modelling approach according to the methods described in [ 9].
In order to validate the methodology a simulated study was conducted.
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The simulated study is followed by a study involving actual measured data for the case of an F-shape test structure.
When simulated studies are not biased, the AITC method had the largest MSE, as compared with DTC and MTC methods.
58– 61 Titration rates from low-intensity statins to higher-intensity treatment are also low according to several studies, 44, 62, 63 in addition to the pharmacy claims data from the US against which the Archimedes-simulated study was calibrated.
The simulated study replicates were terminated when the target number of disease progression or death events were reached (e.g., 350 as in the NO16853 study or larger).
The simulated case study was a generic south-oriented classroom located in Cairo' desert in Egypt.
A simulated shipping study was designed to understand the effect of individual shipping stresses on re-dispersion time and product quality.
The simulated client study was conducted in facilities where providers were not interviewed for the facility assessment.
A program simulating the study was used to determine a sample size of 4800 patients has 80% power to declare non-inferiority.
A simulated case study is used to assess the impact of CGMSs both in the optimal clinical test design problem and in the subsequent parameter estimation for the identification of a complex physiological model of glucose homeostasis.
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