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After generating the simulated occurrence of GR and AP-1 canonical motifs, we calculated the distance between the two motifs.
If the canonical motif occurs in the chromosome M times, then we random selected M positions from {X+1, X+2, …, X+n} as the simulated occurrence.
To statistically evaluate the association of the 21-, 22- and 24-nt siRNA loci with genic, intergenic and repetitive regions, we compared the observed occurrence with the simulated occurrence of 21-, 22- and 24-nt siRNA loci in association with the three genomic region types (Mehtods).
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Finally, the figure shows that the native and simulated occurrences are strongly correlated with each other, especially the all-motifs, 4fold, and 6fold groups.
Although accurate in capturing the dynamic of biomolecular interaction systems, SSA becomes computationally intractable, if the time scales of involved interaction events are disparate, because it simulates every single biomolecular interaction event, spending inordinate amounts on fast reactions for very few simulated occurrences of slow reactions.
To examine the adaptive changes in the number of stem cells, the epithelium homeostasis was reduced by 50%, simulating occurrence of intestinal lesions causing damage to the differentiated epithelium.
The simulated EPB occurrence was well correlated with DMSP satellite observations.
These effects were investigated by applying an environmental envelope method (BIOCLIM) and three regression-based methods: logistic regression (LR), generalized additive modelling (GAM), and classification and regression tree (CART) to simulated species occurrence data.
We simulated the occurrence of randomly distributed SNPs in Affymetrix probes using a conservative prediction of one SNP per 1000 base pairs [11].
We simulated the occurrence of randomly distributed SNPs in the Affymetrix mouse probes using a conservative estimate of one SNP per 1000 base pairs.
For each woman, we simulated the occurrence of breast cancer, its natural course, and the participation in mammography screening (fig 1).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com