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Secondly, we aim to simulate adaptation of RT planning during the treatment course in order to personalise RT delivery in response to individual lung injury.
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We simulated adaptation from de novo mutation in a modified Wright Fisher model with selection.
We simulated adaptation from de novo mutation in cycling populations and an expanding population using the Wright Fisher models specified above.
Individual-based models (IBMs) can be used to simulate intergenerational adaptation by implementing model organisms parameterized with structures analogous to genetic chromosomes.
First, we embed the vascular system into healthy tissue and then simulate vessel adaptation until a steady-state is reached.
This linear increase in temperature mortality threshold attempts to simulate corals' adaptation to higher levels of heat stress (at 0. 1°C/decade), and assumes that decreasing Ωa will not have a significant effect on calcification rates.
Ruimerman et al. [ 216] applied this model to simulate bone adaptation under the influence of changes in the load orientation.
We used PDG to simulate local adaptation in a continuous tree population that expands along an elevational gradient based on experimental data collected from Fagus sylvatica populations on Mont Ventoux in southeastern France.
The specific values of the properties were adopted from previous studies [ 30– 32] and are listed in Table 2. Nonlinear frictional contact elements were used to simulate the adaptation between the bone and the implant.
In that respect, one advantage of optimality-based models is that they simulate the adaptation of plants to their environment based on a principle that is not expected to change as the environment changes and hence their performance for predictions into the future is not expected to be fundamentally worse than that for predicting the past.
In Step 2, we simulated trabecular adaptation in human proximal femur during growth with the reference value derived in Step 1.
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