Sentence examples for simply bound to from inspiring English sources

"Others would say don't do it because it's impossible to depict; you are just simply bound to fail.

Although the spatial distribution of RNA polymerase II can be used to assess transcriptional regulation, polymerase occupancy alone, as detected by chromatin immunoprecipitation, cannot discriminate between polymerases that are simply bound to promoters and those that are transcriptionally engaged.

Unlike canonical protease inhibitors that simply bind to the protease active site, inhibition by serpins requires mechanical deformation of the protease active site, mediated by extensive structural rearrangements and repacking of the serpin structure.

In other words, CIC a native ATXN1 interactor does not discern between a nonpathogenic wild type ATXN1 dimer and a pathologically expanded ATXN1 dimer, and interacts with either; it simply binds to ATXN1 to form a functional transcriptional repressor complex or a dysfunctional oligomeric complex, depending on the polyglutamine tract.

As a result, the substrate does not simply bind to a rigid active site; the amino acid side-chains that make up the active site are molded into the precise positions that enable the enzyme to perform its catalytic function.

HCV may simply bind to circulating lipoproteins but an interference occurring during lipoprotein synthesis by infected hepatocytes may also lead to the generation of a hybrid-virus like particle.

No evidence for binding was observed for the other peptides; this suggested that the Grb2-SH2 domain will not simply bind to a phosphoryl group presented in the correct peptide context, or to an aromatic ring.

Chemical entities with affinity for the resting state of VGSCs, like TTX, simply bind to the extracellular regions of VGSCs, block the passage of ions and cannot be removed by either changing the membrane voltage or the gating of the channel.

The primitive ribosome might simply have bound to one end of the mRNA and continued until it fell off the other end.

Other residues that were previously considered strictly conserved and catalytically important have turned out not to be conserved, such as the above-mentioned glutamate residue (which throughout this Review will be named simply glutamate) bound to center II in several oxidized SORs, or the lysine residue, also at the −(E)(K HxP– motif, and located close to the catalytic site.

He was taken to court by police, but she offered no evidence and he was simply bound over to keep the peace.