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Fig. 3 Framework validation method.

Input prediction model, validation method.

Model validation −What kind of validation method is used?

= Validation method.

HALR developed the PSI-BLAST validation method.

AH and MT developed the validation method.

We used an indirect validation method.

A cross-validation method was used to estimate the date of samples with known age23.

Fig. 9 Cross-validation method.

Figure 9 shows the cross-validation method.

We implemented a Monte Carlo Cross-Validation method.