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Indeed, present day archaea, which possess a simplified form of the eukaryotic replication machinery, presumably reflective of a more ancestral state, have a simplified GINS factor.
The crenarchaeon Sulfolobus solfataricus has been shown to possess a simplified complement of the eukaryotic DNA replication machinery, and thus serves as a model system for analysis of replication proteins (Dionne et al, 2003a).
Furthermore, the archaeal DNA replication system appears to be a simplified version of the eukaryotic one.
GINS is an essential eukaryotic DNA replication factor that is found in a simplified form in Archaea.
The archaeal replication machinery is generally considered to be a simplified version of the eukaryotic apparatus, which usually harbors more components (fig. 1).
Our study emphasises the need for a simplified cell culture or an animal model to study the overall replication cycle of human bocavirus; until such a model is available, it is crucial to collect more clinical samples in larger amounts in order to enable further analyses on the viral genome structure and replication intermediates.
Finally, we used this notation to manually construct a simplified map that provides a high-level overview of the IAV replication cycle.
The generally accepted simplified paradigm states that double-stranded breaks activate ataxia telangiectasia mutated (ATM) kinase, while stalled replication forks and single stranded DNA damage activates ATM and Rad3- related (ATR) kinases [1], [2], [3], [4], [5].
