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Cybernetic modeling framework is based on the incorporation of internal dynamics of simplified regulated metabolic network of cell and the effects of external environment (Murthy et al. 2012).
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The networks I use here are simplified in that each gene is regulated by a single upstream factor, whereas real genes are often multiply regulated.
In a simplified model, the gene expression is regulated by intrinsic and extrinsic cellular responses regulated by signaling pathways that are defined in a protein network.
Since this approach can be used only for chloroplast, we also tested a simplified version for cyanobacteria described with the simplest Michaelis-Menten kinetics, regulated only by concentration of PGA and estimated kM.
Using simplified differential display analysis, 10 genes were identified as being developmentally regulated, and the expression of sweetpotato class I knotted1-like homeobox genes in the storage roots was further confirmed [ 20, 21].
In the late sixteenth century, the language of music was undergoing an epochal transition: composers were setting aside the established modes, or scale-like organizing patterns, that had regulated music since the medieval period, and were moving toward a simplified network of major and minor keys.
In particular, the braking forces are usually regulated, e.g. on freight trains, using a load-sensing pressure relay, simplified scheme of which is represented in Fig. 4.
But even democratic liberalism, Trilling believed, exhibited a simplified view of the world and an unwavering conviction about how the world might be regulated.
The need for more simplified dosing instructions has been demonstrated in several such studies, but change has been slow to come, partly because pharmacists in each state are regulated by a different board of pharmacy.
Regulated more?
Not regulated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com