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When monoclonal ANAs and non-ANAs generated from a genetically simplified mouse model of lupus, B6.Sle1, were recently compared, the ANAs exhibited three sequence motifs in their immunoglobulin heavy chains, including increased cationicity in CDR3 ("motif A"), reduced anionicity in CDR2 ("motif B") and increased aspartate at H50 ("motif C").
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Still, Studer notes that the mouse model is a simplified version of Parkinson's disease, so the challenges in treating human patients with therapeutic cloning are still large.
In contrast to inconclusive findings in human genetic studies, a mutant mouse model is a simplified and alternative approach to determining the biological functions of AKT1 and its possible role in the pathogenesis of schizophrenia.
Our periodontitis mouse model is a very simplified simulation of clinical periodontitis seen in the patient population.
A mouse model, for example, is by no means a simplified description of a human disease as could be misunderstood by a mathematician.
We decided to use a mouse model to seek experimental evidence for the observed correlation, as mice have a simplified CD33rSiglec profile compared to other mammalian model systems, in terms of number of genes and expression patterns.
xenograft mouse model [9].
The second strategy is using mouse model.
The NMJs in the mouse models are both larger and greatly simplified in ultrastructure compared with WT.
There are now mouse models of Parkinson's.
Mouse models have various advantages.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com