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"The simplification work we have already done is serving us well as we face the tougher external environment.
The model simplification work flow combines delocalized parameter estimation, identifiability testing, variance analysis, and goodness of fit testing.
In this section we apply the model simplification work flow to the truncated JAK-STAT model from Figure 1.
The proposed model simplification work flow is applied to a model of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling, which is based on the model by Yamada et al. [ 36].
The purpose of this simplification work was to develop a set of generic statements that could be configured as the 'front end' of a web enabled toolkit for users of NPT.
Most importantly, the single step model simplification described in [ 2] is extended to a multi-step model simplification work flow in which new estimations are carried out after each model simplification step.
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When simplification works, it can indeed be very effective.
Furthermore, conventions of cartographic representation, particularly the need for generalization and simplification, worked to reinforce and heighten the original modernist, engineering ethos.
That is the principal reason this simplification works.
Rule ((mathtt {CONJ} )) specifies that constraint set simplification works, unlike constraint set satisfiability, by performing a union of the result of simplifying each constraint in the constraint set, separately.
This simplification works quite well, as long as the assumption holds, that most of the cars are able to finish their routes within one unit of discrete time, i.e., here 1 h.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com