ATV has also been studied in several simplification trials.
During model simplification, the interaction of trial number with target type dropped out of the model, suggesting that learning rates were not different for different targets.
During model simplification, the interaction of trial number with target type dropped out of the model, suggesting that people did not differentially change their capture strategy with different targets.
Currently, there is considerable interest and ongoing trials in ART simplification strategies [19], such as using a single boosted protease inhibitor as a maintenance regimen in those who are stable and virologically suppressed on ART [20], which will also reduce the cost of lifelong ART.
However, in treatment-experienced adults, there was no difference in AST and ALT between TDF/FTC and ABC/3TC in a combined analysis of 2 trials (BICOMBO trial in Spain and Simplification of antiretroviral therapy with Tenofovir-Emtricitabine or Abacavir-Lamivudine trial (STEAL) trial in Australia) [ 35].
In this trial, the investigators evaluated how simplification of therapy could affect adherence, quality of life, and subjective perception of health status, and how these variables influenced one another.
Protease inhibitor monotherapy (PImono) has been explored as treatment simplification strategy in a number of randomised clinical trials [ 4- 6].
5 9 However, the CTD failed to achieve its intended impact on the simplification and harmonisation of administrative provisions governing clinical trials, 9 and thus on the level of European clinical research activity.
Since this work was focused on PF, criteria that were not essential for feasibility were removed (e.g. in the case of the NCT01018173 trial, 26 criteria were extracted after the simplification, but for feasibility only 5 were relevant).
Homogenization of outcomes definition, outcomes measure and simplification of eligibility criteria are probably needed for further trials.
