Experience from vertical HIV programmes in resource-limited settings has led to simplification of treatment with standardised treatment protocols, fixed-dose combination drug regimens, minimal monitoring, and intensive adherence support.
Future objectives for the development of new anti-parkinsonian medications should include: the prevention of disease progression, the mitigation or prevention of medication-related motor complications, the simplification of treatment regimens, and restorative treatments to provide new neurons or stimulate the growth of surviving cells.
The European Society for Clinical Microbiology and Infectious Diseases (ESCMID) suggests simplification of treatment by stepping down to oral fluconazole after 10 days of treatment if the patient is stable, and tolerates oral therapy, and if the Candida species is susceptible [ 19].
Further simplification of treatment and identification of more effective drug combinations are needed to improve patient adherence, the most significant cause of treatment failure.
Viewed as a cyclical process, the inattention to some principles -- simplification, equal treatment of equals, efficiency -- eventually becomes too great, and there is widespread agreement to switch focus on them".
A sensitivity analysis was performed by excluding simplification of treatment from other causes of cART modification.
These offer potential advantages, including simplification of treatment regimens, more convenient drug administration and reduced healthcare costs [ 5, 9, 10].
Simplification of treatment, including decreasing the frequency of dosing, is likely to increase convenience and enhance adherence to antiretroviral therapy (ART) [ 1].
7 Increasingly, a single-pill combination containing two antihypertensive drugs with complementary mechanisms of action offers potential advantages, including simplification of treatment regimens, more convenient drug administration, increased compliance, and reduced health care costs.
Single-pill combinations (SPCs) containing two or more antihypertensive agents with complementary mechanisms of action offer potential advantages over free-drug combinations, including simplification of treatment regimens, convenience and reduced costs.
