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This paper describes the synthesis and the in vitro antimalarial profile of two new imidazo[1,2-a]pyridine derivatives 4·HCl and 13·HCl, structurally proposed as mefloquine (1) analogues, by exploring bioisosterism and molecular simplification tools.
Sentence simplification tools, such as iSimp, transform complicated sentences into sentences easier to comprehend and process.
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O2Simplify is a more complicated simplification tool, consisting of innumerable lists.
For performance optimization, we also integrated an abbreviation resolution and composite mention simplification tool in this step.
In concept normalization step, we applied our previous system, GenNorm, combined with a composite mention simplification tool (i.e., SimConcept) and an abbreviation resolution tool (i.e., Ab3P) for optimized performance.
"I see it as a life-simplification tool," he says.The name originates from the sci-fi novel "Make Room! Make Room!" in which people in an overcrowded, apocalyptic world live on foods made of soy and lentils.
In order to do so employees need to be cognizant of design simplification strategies and tools, thus requiring a greater need for education and training.
We know that this is a simplification, a working tool that enables inferences about certain specific structures (Pavlicev and Hansen 2011).
ELP-s was compared with the two leading commercial LCA softwares, GaBi and SimaPro, based on two reference buildings: (i) a concrete and (ii) a wooden building, in order to examine the importance of material selection and the simplification of the tool.
Subsequently, the grading system was compressed to four grades for simplification of the tool.
Yet respondents identified several strategies for improving integration through tool simplification, enhanced teamwork and training, improved Quitline feedback, and patient education.
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