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The phrase "simplest of which" is grammatically correct and can be used in written English.
It is typically used to refer back to the simplest thing among a group of options that have been previously mentioned or implied. For example: "We offer a variety of different packages for our customers, each with its own unique features and benefits. Our cheapest option is the basic package, but for those who are looking for more advanced options, we also have our premium and deluxe packages. However, the simplest of which is the basic package."
Exact(25)
Mr. Rodriguez's other treat was long dresses, the simplest of which were in 1940s-style print silks with asymmetrical hems.
Tierney mentioned various dodges crafted for coming out of X, the simplest of which was pure speed — the "speed dodge," the "rush dodge," the "bull dodge".
UNDER $100 A gravure (engraving), featuring a scene from the Greek myths or ancient plays, the simplest of which cost as little as 5 euros (about $7).
There are various theories about why Mormons are smitten with Jell-O, the simplest of which is that in a life bereft of tobacco, alcohol and caffeine, sugar is their guilty pleasure.
The listener is increasingly pushed towards allegorical interpretations, the simplest of which makes an apposite message for today's world: Pi subdues the potential killer without violence, co-existing through understanding and mutual respect for the other's territory.
When you respond to a response, it simply remains in the same column and it becomes impossible to know for whom the response is intended other than by saying @username We're playing with a few solutions to this, the simplest of which is putting back essentially the same timestamps as exist in the old platform.
Similar(35)
"There are certainly a few 'cheats' to the Confide system, the most obvious and simple of which is using a second device to photograph or make a video recording of the screen.
The chemical reaction can be of any order, but the most simple of which is the chemical reaction of first order where the reaction rate and species concentration are directly proportional to each other.
There are a number of algorithms for identifying orthologous segments, the most simple of which is GRIMM-Synteny [33] where anchors at distances less than a user-specified threshold are merged into "syntenic blocks".
The LRTs used compare two probabilistic models of variable ω ratios among sites, the simpler of which does not allow sites with ω >1 and a more general which does [ 21] (model M7 vs M8).
Cyanobacteria generally harbor a substantial number of genes that encode elements of two-component regulatory systems, the most simple of which is represented by histidine kinase and a response regulator.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com