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We have tried to estimate the free energies of unfolding of the two proteins by fitting the data to the simplest models that could reasonably explain the experimental measurements, as summarized in Table 2.
These are the simplest models that capture the key elements of population genetics (genetic drift, fixation probability, fixation time,…) with the fewest possible ingredients.
In developing logistic models, the strategy was to fit the simplest models that adequately fit the data to adjust for potential confounding.
The data were fit by numerical integration methods using Dynafit 3 and employed the simplest models that preserved the information content of the data sets.
In each of these subsets, we included the genes annotated as TF targets in the ConceptGen analysis, as well as the TF, and used parameter settings to produce the most parsimonious models possible (i.e. the simplest models that include all of the input genes).
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The remaining 20% are Sportsters, Harley's oldest, simplest model, that go for about $8,000.
However, we prefer the simplest model that is able to correct for the temperature sensitivity.
The Lambda-CDM model is the standard model of Big Bang cosmology, the simplest model that provides a reasonably good account of various observations about the Universe.
Figure 1e is a network generated by the duplication-divergence (DD) model, which is the simplest model that has only one control parameter.
The most valuable model is the simplest model that retains enough adaptability to explain the real system behaviour and also matches the system's properties.
The simplest model that accomodates our findings would be that β2ARs associate with each other transiently, such that there is a monomer-dimer equilibrium on the cell surface.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com