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Complex spikes are often followed by a pause of several hundred milliseconds during which simple spike activity is suppressed.
This could be due to entrainment of simple spike firing into the stereotyped bursting.
Electrophysiological response to stimulation was assessed by complex and simple spike analysis.
These latter interrupt simple spike firing during a 10 50 ms period, the so-called pause generated complex spike.
This pause may be followed by a long-lasting (∼500 ms) inhibition or facilitation of simple spike [15].
Around 20 ms after each stimulation, a complex spike was fired (Fig. 6B), followed by a prolonged inhibition (∼500 ms) of simple spike firing (Fig. 6C).
Blocking TRPC3 attenuates the simple spike frequency difference.
Simple spike firing activity differs between Purkinje cell populations.
10.7554/eLife.02536.006 Figure 2. Simple spike firing frequency correlates with the zebrin identity of Purkinje cells.
Simple spike firing rates were calculated using the reciprocal interval method (Lisberger and Pavelko, 1986).
(J ) Simple spike regularity is not different between Z+ and Z− PCs (CV2: t = 1.147, p=0.234).
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