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The rules of the game are simple: shuffle the deck, draw as many cards as you like, and voilá — an improvisational score.
Where the blues rock drumming style started out largely as simple shuffle beats on small kits, drummers began using a more muscular, complex, and amplified approach to match and be heard against the increasingly loud guitar.
Perform the "snake", which is a quite simple shuffle where you hold the deck in your right hand and hand off cards into your left hand until the deck is totally in your left hand.
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Well into his 90s, it took no prompting for the white-haired, gentlemanly Ebsen to break into a "shim-sham-shimmy," a simple shuffle-tap dance followed by outstretched arms and a shimmy: the traditional hoofers' hello.
A more recent paper by Li and colleagues [13] describes combination of multiple crosses using cross as a covariate, and outlines a permutation method that retains stratification of phenotypes by cross for determining genome-wide significance, which should work well when simple shuffling of genotypes and phenotypes within cross is sufficient to provide appropriate randomization within data set.
In every instance this simple shuffling of the data completely abrogated detection of the enrichment signal, supporting the SBSE score as a robust estimate of seed enrichment in a differentially expressed dataset.
In every instance this simple shuffling of the data completely abrogated the enrichment trace and further supported our assumption that ranked expression profiles can be used to estimate miRNA target enrichment.
For the sake of clarity, this comparison was limited to wild-type enzymes and chimeric variants of the Chim series, since these variants exhibit a simpler shuffling in sequences than that of ChiMo series.
Howard was waived just three days after he had two fumbles on only eight carries in a 39-36 loss to the Baltimore Ravens, a move Coughlin initially described as a simple roster shuffle brought on by more injuries.
The 146 bp sequences flanking every existing mutation (i.e., −73 … −1, +1 … +73) were randomized with a simple card shuffling algorithm, thus preserving local AT content while removing any sequence-based contextual information associated with each given mutation.
As demonstrated by synthetic promoter shuffling in our simple experimental system, shuffling of regulator binding sites can indeed lead to dramatic changes from one logic type to another (e.g. F16 to F23 and F26 to F28).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com