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The lack of control is alarming and potentially dangerous, especially if it is found to be triggered by a simple loss of traction.
But the lack of activity also reflects HSBC's losses in America, which weakened its balance-sheet, and a simple loss of nerve.HSBC had a relatively good financial crisis.
From the blogs Simple loss of faith, February 2009 We no longer have faith in the government, the education system and the health-care system, etc.
These results demonstrate that point mutant p53 alleles expressed under physiological control have enhanced oncogenic potential beyond the simple loss of p53 function.
Any economic recovery in this country will be most threatened not by the complex tides of finance but by the simple loss of millions of hours of office productivity to Plants vs. Zombies' ravenous hordes.
The simple loss of papers and subscriptions from UC isn't going to be enough to drive Elsevier to change unless it thinks this is a harbinger of other things.
Similar(16)
With the current available mutation data, it seems that CNVs in PINK1 are less common than simple loss-of-function mutations (see Supp. Table S4-2).
The polyglutamine diseases do not appear to be the result of a simple loss-of-function mechanism, since they show dominant inheritance and share a number of clinical features.
The first mouse models were simple loss-of-function alleles caused by gross deletion of most of the coding sequence (3, 4), but knock-in mutations corresponding to specific RTT-causing mutations (5, 6) offer the opportunity for deeper understanding.
Interestingly, a simple loss-of-function genome scan, for genotype-phenotype covariation only in the putative loss-of-function allele, is able to precisely identify the Tannin1 gene without considering relatedness.
Here, we take advantage of high-resolution genotyping-by-sequencing single-nucleotide polymorphism (SNP) maps to compare the ability of several genome-wide mapping approaches to identify known flavonoid pigmentation loci, contrast linear model GWAS to a simple loss-of-function genome scan, and use GWAS to identify additional loci that may underlie flavonoid pigmentation in sorghum.
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