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However, this simple inflammatory response is unlikely to fully account for the massive neutrophil influx observed with DMXAA-treated tumours.
In addition, differentiating between a simple inflammatory response and a true infectious complication following abdominal surgery still remains a challenge in clinical practice.
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However simple steatosis may incite an inflammatory response leading to steatohepatitis.
Using a simple measurable readout of the inflammatory response (quantifying numbers of neutrophils at tail fin wounds), we identified a large number of drugs that diminished neutrophil recruitment, most of which have not previously been described as modulators of the inflammatory response.
CD4+ count and mHLA-DR could be simple tools to assess the systemic inflammatory response after OHCA.
As haematological tests are routinely conducted in patients with RCC before medical intervention, NLR acts as a simple, robust and convenient parameter of the inflammatory response.
Thus, invading S. Typhi may follow a simple default pathway favoring limiting activation of the inflammatory response.
Studies have shown that the sympathetic nerves can negatively or positively modulate the inflammatory response in a context-dependent manner.58,59,60 Our study shows that a simple mechanical abrasion of the corneal epithelium can quickly activate the sympathetic nervous system.
Systemic inflammatory response syndrome and sepsis are diseases of the immune system rather than simple effects of a causative agent.
Hence, the in vivo inflammatory response can either be predicted by BET surface area or by a simple quantitative model, based on in vitro OxPot and Cyp1a1 induction.
This further highlights the difficulty in deriving a simple measure of PM inflammatory potential, because the induction of separate pathways can elicit a common final inflammatory response.
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