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Importantly, however, such putative indirect selection does not affect our conclusions for simple genetic effects underlying the increased tendency of females to produce only sons across successive introgression generations.
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The relation between E and G is modeled as a simple linear regression assuming additive genetic effects at the genetic locus: The likelihood ratio test constrains β EG (1)≡0 under the null hypothesis and has 1 df.
The study is important, because it shows that "relatively simple genetic changes can have profound effects," says R. Craig Albertson, an evolutionary biologist at the Forsyth Institute in Boston, Massachusetts.
It is largely unknown if trait decay typically stems from multiple mutations with small effects, or rather has a simple genetic architecture involving few loci with major phenotypic effects (Jeffery, 2009; Lahti et al., 2009).
We carried out meta-analyses of these 35 genetic variants under simple genetic models using both the random-effects model and fixed-effects model [ 22, 23].
How common are gene gene interactions in the absence of significant marginal effects likely to be? Moore (2003) argues that a simple genetic architecture characterized by SNPs with large marginal effects is an unrealistic assumption for many common human diseases.
The design parameters of the LQG method are automatically adjusted by using a simple genetic algorithm (SGA) to achieve a better global control effect.
We show how direct and maternal genetic effects can be estimated with a simpler analysis based on the reduced animal model and we illustrate the method using farrowing survival information on 118 193 piglets in 10 314 litters.
It has been suggested that strong directional selection and simple genetic architecture should limit TS because they point the phenotypic effects of QTL in the same direction; this would essentially constrain diversification by hybridization [ 21].
In general, ACF percentage was a better trait for QTL mapping in our study probably because it is a marker of a specific biological process with a more simple genetic architecture (i.e. smaller number of loci with larger effects).
If the simple close linkage is the major reason, the directions of the genetic effects for different QTLs may be different, although the coincidence of the locations can still be expected (Zhuang et al. 1997).
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