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The prodrug was mixed with a PEGylated lipid to form a simple but multifunctional hybrid micelle system, which can realize high drug loading capability and biocompatibility, extended blood circulation time, inhibited drug resistance in cancer cells, improved therapeutic response, reduced side effects, and easy functionalities for targeting delivery.
Zhu et al. presented a simple but multifunctional micellar platform constructed by a matrix metalloproteinase 2 (MMP2)–sensitive copolymer (PEG-pp-PEI-PE) via self-assembly for tumor-targeted siRNA and drug co-delivery.
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"His color and pattern choices always look fresh, and he's so thoughtful about making simple things multifunctional," said John Remington, the vice president for events marketing and communication at Target.
"Not prescriptive, but multifunctional and playful," said Michael Marriott, who organized the designers for Oreka Kids.
The toolkits of hunter gatherers vary considerably over space and through time from simple and multifunctional, to complex and specialized.
The straightforward non-covalent combination of MSN and gold-protein cluster bioconjugates thus leads to a simple, yet multifunctional nanotheranostic for the next generation of cancer treatments.
In order for multifunctional MRI data to inform on patient management, multiparametric data need to be communicated to oncologists/urologists in a simple but meaningful way.
Simple but useful.
His food is simple, but not simple.
It was simple but effective.
A simple, but deadly, mistake!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com