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First, affinity propagation defines a similarity matrix.
(D) is a similarity matrix of drugs, and (T) is a similarity matrix of targets.
The fuzzy measure is used to construct similarity matrix.
Fig. 1 Transforming a similarity matrix to a similarity network.
Algorithm 1 parallelized constructing the reduce function in similarity matrix.
Figure 3 Example of a spectra similarity matrix.
We define the final drug drug similarity matrix S d by taking a linear combination of the chemical similarity matrix (C s ) and target sharing similarity matrix (( C_{s}^{n} )).
The MST coefficient was taken from the composite similarity matrix.
Each isolate was thus assigned a 'polyphasic profile' (PP) contributing to the composite similarity matrix.
A conventional UPGMA dendrogram based on the composite similarity matrix is shown in Figure S2.
For each dataset a similarity matrix was generated using the Bray Curtis similarity measure.
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