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The IsoCleft program, developed for the detection of binding-site 3D local atomic similarities uses an all atom (non-simplified) representation, in a two-stage graph-matching process.
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They then calculated drug-drug pair similarities using four features: phenotypic similarity, therapeutic similarity, chemical structure similarity, and genomic similarity.
The data matrix was used to calculate genetic similarities using the Jaccard (1908) coefficient.
The data matrix was used to calculate genetic similarities using the Jaccard coefficient (Jaccard 1908).
Functional similarity (D F ) The intersection of functional similarities is divided by union of functional similarities, using any similarity coefficient methods (e.g. Jaccard similarity coefficients).
Description similarity (D S ) The intersection of description similarities is divided by union of description similarities, using any similarity coefficient methods (e.g. Jaccard similarity coefficients).
The similarities these recommendations are based on, however, are directly taken from the similarities used in the recommendation algorithms.
It thinks in pictures, is non-verbal and seeks similarities using the information that streams in through our senses to determine what an experience looks, smells, tastes, feels and sounds like.
Amino acid similarities used in multiple sequence alignments were as described previously [21].
The sequences were then screened for sequence similarities using tBLASTx and BLASTn against the nr database in GenBank.
We assessed these similarities using each observer's confusion matrix.
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