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TRPC channels have been classified as TRPC1, TRPC2, TRPC3/6/7 and TRPC4/5 on the basis of structural similarities and functions.
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Through the statistical modeling process we shed light on the variability in the relationship between sequence similarity and function similarity.
However, some PHD fingers may be different from other PHD fingers in both the sequence similarity and function.
However, the degree of variability in the relationship between sequence similarity and function similarity in moderate sequence similarity ranges currently places constraints on the predictive accuracy of ours or any model.
The gene group analysis that we performed provides one way to summarize the statistical evidence for association between a trait and multiple genetic variants across groups of genes that share sequence similarity and function.
Based on sequence similarity and function, seven TRPC homologs (TRPC1-7) can be subdivided into four groups: TRPC 4/5 (group 1), TRPC 1 (group 2), TRPC 3/6/7 (group 3), and TRPC 2 (group 4) [9], [9].
An important part of the annotation puzzle that is missing in particular is an in-depth understanding of the relationship between sequence similarity and function similarity over a continuous range and the amount of variability inherent in the relationship over all ranges of sequence similarity.
PARP is a family of proteins loosely based on structural similarity and function [1].
In the features, the similarity and function of the identified genes has been annotated by the authors according to Gene Ontology.
The constitutive androstane receptor (CAR, gene symbol NR1I3) is closely related to PXR with regard to sequence similarity and function.
The sequence comparisons within and across the four genomes provide a global view on the relationship between sequence similarity and function similarity.
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