As archived meeting minutes show, one scientist who opposed the simian virus studies on prisoners was told that the virus was safe because millions of Americans had already (accidentally) been exposed to it, though the point of the research was to learn more about the virus' effect on people.
The predominance of ape specimens from previous simian retrovirus studies are non-invasively collected feces and urine samples and while SIV and SFV have been successfully detected in these body fluids, the detection of PTLV in these samples has not yet been reported.
A number of viruses use caveolae for infection [10], [13], [14], [15], [16] and much of our knowledge of caveolae comes from studies with simian virus-40 [17], [18], [18].
Two studies in simian immunodeficiency virus-infected rhesus monkeys have demonstrated that lymphatic tissues act as the anatomic compartment for active viral replication during antiretroviral therapy.
GLUL is shown to be associated with schizophrenia [ 35] moreover, studies in simian immunodeficiency virus infected macaque have also shown dense perineuronal GLUL accumulation thus indicating their role in the host response to viral infection [ 36].
Studies with simian immunodeficiency virus (SIV) showed that alcohol-exposed macaques had higher levels of cerebrospinal fluid (CSF) virus, plasma viremia, and more severe alterations in peripheral blood mononuclear cells (PBMC) subset numbers.
Dr. Ginsberg spent the latter part of his career at the National Institute of Allergy and Infectious Diseases studying the simian AIDS virus, called S.I.V., to learn how it injures a host after infecting it.
The present study utilizes simian immunodeficiency virus (SIV) to identify viral epitopes that conferred antibody neutralization to clone SIV/17E-CL, an in vivo variant derived from neutralization resistant SIVmac239.
Hahn, a virologist from the University of Alabama at Birmingham and a discoverer of the simian virus, called the study "a very nice paper," adding, "This is what people like us have been looking for".
Therefore, the use of murine and simian tissues in this study does not qualify as vertebrate animal research.
