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The remaining coins in the five silver group and the copper group were all found in the Vaigai river bed near Madurai.
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Four of the six silver groups have been assigned a date close to the end of the Mauryan rule, c. 187 BCE.
Thus, both groups promote pleurodesis; however, the silver nitrate group presented greater aggression to the pulmonary parenchyma, introducing copaiba oil as a potential treatment for the induction of pleurodesis with milder side effects.
It is found that the most significant adverse effect was severe flank pain, with an incidence of 11% in the silver nitrate group and 2% in the povidone iodine group.
In the visceral pleura, edema was more intensely present in the 24 h silver nitrate group when compared to the copaiba group (P = 0.041).
The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed.
Functional studies of HMAs have shown that these transporters can be divided into two subgroups based on their metal substrate specificity: a copper (Cu /silver (Ag) group and a zinc (Zn)/cobalt (Co /cadmium (Cd)/lead (Pb) group (4).
Greater macroscopic inflammatory reactions were observed in the rats that received copaiba oil, in all the times of sacrifice, when compared to the silver nitrate group, with statistical significance in the 24-hour group (P < 0.05).
The presence of bronchopneumonia was higher in the 24 h silver nitrate group (n = 4) in relation to the copaiba group (n = 0).
In the 48 and 72 h groups, the presence of edema was more frequent in the silver nitrate group (Table 2).
The alveolar edema difference was more evident in the 24 h 0.5% silver nitrate group, with statistical significance (P = 0.003), when compared to the copaiba oil group.
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