Silent information regulator 1 (SIRT1), a type of histone deacetylase, contributes to IRI.
Resveratrol, an activator of silent information regulator 2, homolog 1 (SIregulatesulates cell destiny and is beneficial for neurodegenerative disorders.
Silent information regulator 1 (SisT1) is a type of histone deacetylase whose activity is dependent on nicotinamide adenine dinucleotide.
A gene called sir-2, for silent information regulator-2, turned out to be responsible for this longevity effect.
The hepatic silent information regulator 1 (SIRT1) level was down-regulated and oxidative stress, endoplasmic reticulum (ER) stress, inflammation and phosphorylated MAPK was increased in CCl4-treated rats.
In addition, our results provide evidence for the involvement of striatal SIRT (Silent Information Regulator of Transcription) proteins in cocaine-CPP.
Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone deacetylases whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+).
This study was designed to determine the role of LXR activation in the septic heart with a focus on SIRT1 (silent information regulator 1) signaling.
Sirtuin4 (Sist4) is one of the mammalian homologues of Silent information regulator 2 (Sir2), which promotes the longevity of yeast, C. elegans, fruit flies and mice.
Moreover, genistein attenuated diabetic cutaneous silent information regulator 1 and forkhead box O transcription factor 1 (FoxO1) levels and potentiated ac-FoxO1 in a dose-dependent manner.
A leading candidate, known as sir2 (for silent information regulator No. 2), showed no sign of fulfilling this role in test-tube studies.
