Exact(47)
This index aims at comparing the ratio of non-synonymous (= amino acid changing) to synonymous (silent) changes within species (π n / π s ) and between species (D n / D s ): NI is one when evolution is neutral, higher than one under purifying selection, and lower than one in case of adaptation.
Different pathologies affecting the aortic root can cause serious clinical conditions with/without aortic valve dysfunction or silent changes, which can be fatal.
Thus, silent changes were assigned to eight lineages: m, s, t, y, ty, e, o, and eo.
This strongly suggests that the two silent changes in E1 and NS5B coding sequences are not required for a high level of replication fitness of the chimeric virus.
Indeed, there was a consistent under-representation of silent changes.
In BRG1, two novel silent changes were observed (Table 1).
Similar(13)
There is a silent change among the Arabs in Israel itself.
Two coding sequence variations, both novel, were observed only in patients and predict a silent change, p.S434S, and an amino acid substitution, p.I663V.
This silent change has been previously reported (rs11542704) [ 43].
The oligonucleotides encode desired changes, which result in dominant phenotypes, and a silent change.
Unfortunately, no corresponding normal tissue was available and this silent change was not studied further.
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