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I was a silent carrier for the disease, and we happened to choose a donor who was a silent carrier".
When subsequent generations of mice are exposed to blood or nervous tissues from silent carrier mice, they get the disease.
Coded by a recessive gene, meaning that one can be a silent carrier, the actual disease requires both parents to have the trait.
"If we can find the gene, then we can tell people who is a silent carrier and who isn't," she said.
Because each parent, as a silent carrier, contributes one mutated gene, many children with the disease have two separate defects — for example, a misshapen CFTR mutation and a nonsense mutation, or a misshapen CFTR and a rusty-gate type of mutation.
Few studies have focused on the association between coronary artery disease (CAD) and transfusion naïve thalassemia populations (this term means silent carrier, thalassemia minor or intermedia), who usually had less clinical manifestations and didn't require frequently blood transfusion.
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In other words, mice can be silent carriers of a disease that originated in hamsters.
Nor can much be done for those who have become silent carriers of the hepatitis B virus without ever becoming clinically sick.
Only one victim in every 200 shows symptoms, so when there are 500 paralysis cases, as in the recent Congo Republic outbreak, there are 100,000 more silent carriers.
Many people with hepatitis B are silent carriers, unaware that they are infected, so previous screening methods, like questioning donors about risky behaviors, were often ineffective.
Cystic fibrosis is the most common fatal genetic disorder in North America among Caucasians; some thirty thousand Americans have the disease, and about ten million Americans are silent carriers of the defective cystic-fibrosis gene.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com