Nonetheless, positive selection on silent substitutions affecting transcription and expression cannot be ruled out, although it is unlikely.
To determine whether a decrease in the number of silent genes affects the amounts of the rRNA transcript, we measured 45S pre-rRNA synthesis by qRT-PCR using primers that encompassed the first rRNA processing site.
"It's a silent emergency affecting the poorest and the youngest," Mr. Lake said.
Their report, released in April 2004, reveals a silent epidemic affecting both women and men of working age.
Osteoporosis is a progressive silent disease affecting bone mass and structure, leading to increased susceptibility to fractures [ 1, 2].
7 World Food Programme, "WFP says high food prices a silent tsunami, affecting every continent", WFP, April 2008.
The prevalent silent polymorphism affecting (c.1899 C > T) was also observed in patient 2. Patient 4 carried a reported mutation (c.441G > A) in the TH domain.
We have demonstrated previously that even silent mutations can affect protein folding and function by altering the rate of protein synthesis [44].
Kimchi-Sarfaty et al. [25] suggested that silent SNPs may affect the translation rates of proteins, hence influencing the folding and activity of proteins.
Furthermore, functional change is not expected to affect silent substitution rates.
