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A systematic understanding of the silencing mode employed by nuclear PIWI proteins is therefore a major open question in the field.
The third family member Piwi, however, is enriched in the nucleus, and its silencing mode is much less understood.
The functional state of Drosophila identity genes, i.e., their active or silencing mode, is controlled by the genes of the Polycomb (Pc-G) or trithorax groups (trx-G) (Kennison and Tamkun, 1988; Lewis, 1978).
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Conceptually, two major silencing modes are distinguished, namely transcriptional silencing (TGS) and posttranscriptional silencing (PTGS).
Most animals express multiple PIWI proteins, and these might employ different silencing modes.
"They go into silence mode, then they go into defense mode.
I'm sorry I went into radio silence mode for a while, but I had to keep a low profile while our negotiations were ongoing.
"Apparently that interview put the royal family in their silence mode... so, I gave another interview to break the silence.
A "quiet mode" that silences the between-round chatter and distills HQ to just the questions and puzzles might make it easier to play while multi-tasking.
All of the above has everything to do with our silences and modes of communication.
Some choices, like "Enjoy the Silence" by Depeche Mode, are hard to grasp at first: what does this brooding bit of narcissism have to do with women?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com