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Previous reports suggested that Caspase-2 can limit transformation by silencing expression of the chromosome passenger protein Survivin, a protein highly expressed in proliferating (tumor) cells, with putative albeit disputed anti-apoptotic potential.
These experiments demonstrate that SECs are an excellent screening tool to identify siRNA sequences effective in silencing expression of genes of interest.
We infer from these findings that one mechanism of impairing P. rapae hemocytic immune reactions is by silencing expression of Pr-SR.
The knowledge of host factors gained can potentially be used to inhibit virus replication via gene silencing, expression of dominant negative mutants, or design of specific chemical inhibitors leading to novel specific or broad-range resistance and antiviral tools against RNA plant viruses.
Every time threats of violence succeed in silencing expression, fear's stranglehold on the imagination tightens, stifling our ability to fully explore the world and our place in it.
Surrounding heterochromatin can spread into a normally transcriptionally active gene, silencing expression.
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We then silenced expression of both Nrp genes with shRNA-expressing lentiviruses.
Antisense antimicrobial therapeutics are synthetic oligomers that silence expression of specific genes.
A single copy of the transgene effectively and uniformly silences expression of a target gene (white) in transgenic flies.
We have designed a system to silence expression from nontransposed sequences, making it possible to determine more specifically the amount of expression resulting from transposition.
RNA interference (RNAi) therapy, which silences expression of specific target genes, represents a promising approach for treating viral infections in mammalian hosts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com