Sentence examples for silencer effect from inspiring English sources

Hence, the silencer effect of REPA G tract on exon skipping or its activation of cryptic 3′SS usage is mainly through hnRNP H/F.

To further validate the G tract silencer effect on splicing of endogenous exons, we used RNA interference of hnRNP H/F in human HeLa cells and measured the effect of loss-of-function of these factors on exon usage.

Two of the reporters PAX8 and PAK4 almost completely lost the G tract silencer effect upon knockdown of hnRNP H/F (lanes 3 & 9) whereas the other two exhibited about 29.3% and 13.3% decrease in exon skipping (lanes 5 & 7).

In summary, the identification of hundreds of human 3′SS containing the REPA G tracts and the confirmed splicing silencer effect of representative ones suggest that the highly constrained 3′SS region has been permissive for the emergence of de novo regulatory elements for splicing control of a large group of mammalian genes.

It requires the holo definition of exon or intron elements in context, with integration of multiple splice enhancer and silencer effects [63], [64], [65], [66].

In addition it is observed that, even for relatively high open area porosities, the perforate screen has a significant effect on dissipative silencer performance.

Hence, R functions as silencer in which the repressive effect is dependent on the activation of Otx (Figure 1 and Figure S1(C)).

It is found that the magnetic force imposes both static and dynamic effects on the silencer.

Wave diffraction effects at the silencer terminations are also discussed.

Genetic polymorphisms in intron regions, where splice enhances or silencers bind, can have an effect on alternative splicing [ 42].

When analyzing RP40p::amiRNL-b, we observed a reduction in lateral root formation as well, but effects in the silencer lines appeared less pronounced and more variable than in elp6 mop2.