Sentence examples for silence downstream from inspiring English sources

Although it is hard to prove that automaticity is completely uninfluenced by excitatory current flowing from the rest of the atrium because older studies have described 'triggered automaticity' pacemaker activity is expected to arise only after creating complete electrical silence downstream.

Hypermethylation contributes to carcinogenesis by silencing downstream transcription of key tumour suppressor genes.

Importantly, both endogenous AGO1 and GW182 remained bound to the miRNA reporter, indicating that PABP overexpression suppresses silencing downstream of miRISC binding.

For example, influenza A virus NS1 protein suppresses RNA silencing in plant cells by binding siRNA [ 32], and the expression of HIV-1 Tat protein in N. benthamiana restores GFP fluorescence by inhibiting RNA silencing downstream of the maturation step of dsRNA duplexes [ 33].

EZH2 could epigenetically silence the downstream gene transcription, and it is overexpressed in several types of cancer, including gastric cancer.

If, in addition to CDH3 and HIF-1α, we silence the downstream targets GLUT1 and CAIX (siRNA CDH3 + HIF-1α + GLUT1 + CAIX), there is still a non-cumulative decrease effect in MFE (p = 0.0152).

When epe1Δ mutants are grown on −URA media to select for cells that are expressing the ura4+ gene, the frequency of colonies in which heterochromatin has spread from the L5 to silence the downstream ade6+ is very low.

The data do not indicate any events of spreading of heterochromatic silencing: on the one hand, activation of a subtelomeric SAg does not involve a loss of silencing of downstream genes (between SAg and telomere); on the other hand, the on/off state of the SAg does not apparently influence gene expression level of any neighbouring gene: their expression appears independent.

The efficiency of gene silencing and downstream effect on other genes was evaluated at 24, 48 and 72 hours post-transfection by Real-time RT-qPCR and at 72 hours by Western blot.

Sorting onto ILVs will sequester EGFR in the MVB, effectively silencing its downstream signalling (8, 12).

Methylation of promoter CpG islands is known to inhibit transcriptional initiation and cause permanent silencing of downstream genes.