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It is a small difference that signifies major change.
This structure signifies major changes in technology operations, with companies like Google emerging not merely as internet companies, but major hardware producers.
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I know from talking to Precourt that he wants to focus on improving things that signify "major" league.
It also uses badges to signify major driving accomplishments.
Eras have blurry lines that signify major changes in the artistic progressions of compositional techniques.
This signifies a major, major shift.
Rapid and stable osseointegration signifies a major concern in design of implantable prostheses, which stimulates continuous development of new implant materials and structures.
Recognition of the wide occurrence, significance, and specific characteristics of hypogene speleogenesis during last two decades signifies a major paradigm shift in karst science, previously overwhelmingly dominated by epigene concepts and models.
The new rule signifies a major victory for Unite HERE, the hotel and restaurant workers union, which has been pressing Mr. Paterson and his predecessor, Eliot Spitzer, to issue the directive for more than a year.
Perhaps, judging from recent developments on the island, where the legislature has held its first hearings on the issue, a move that signifies "a major step towards becoming the first Asian territory to approve marriage equality," the Shanghai-based Web site Shanghaiist reported, citing Gay Star News.
This discussion signifies a major sea change, in that cybersecurity and physical security have now effectively overlapped.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com