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Therefore, only when the comparison was based on a large dataset such as SEER the difference between AJCC-6 and AJCC-7 was significantly validated.
Gene-term enrichment analysis of the targets predicted from the significantly validated most differentially expressed miRNAs using KEGG pathways revealed several enriched regulatory pathways.
Using in vitro activated T cells from 8 patients and 8 controls we significantly validated the overexpression of SPATS2L (FC = 1.58, p-value = 0.0014) and KLF6 (FC = 1.23, p-value = 0.024) genes in psoriasis.
Only the 17 significantly validated differentially expressed miRNAs, which were proven significant by qRT-PCR, were used for the subsequent target prediction and functional analysis.> -wrap-foot> *P-values have been corrected for multiple testing by the Benjamini and Hochberg adjustment method.
We performed target prediction for the 17 significantly validated differentially expressed miRNAs (shown in Table 2) to identify the influence of carnitine supplementation on potential target mRNAs in skeletal muscle of obese Zucker rats by combining the results from three online free available algorithms.
Although the effect of combined goserelin and TAM on DFS and OS in premenopausal patients with stages I and II breast cancer was significantly validated by the Austrian Breast and Colorectal Cancer Study Group Trial 5 (Jakesz et al, 2002), we were unable to determine conclusively whether better DFS and OS were reached because of the small sample size and short follow-up time of our study.
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However, as shown in Figure 5, when the SNR is high, increasing M will not affect the value of N ̄ C significantly, which validates the observation in Figure 3 where the credits due to cooperation from secondary users are negligible in high SNR region.
Finally, in CTLA-4 IgG stimulated cells JAG1, MX1 and PTPRC gene expression all increased significantly (p<0.05), validating the newly identified arcs CTLA4 JAG1, and CTLA4 MX1 and the predicted edge PTPRC CTLA4.
However, p75 NTR mRNA levels were significantly reduced, validating data obtained by qRT-PCR.
The expression of p27 has been evaluated by immunohistochemistry using both the TMA technique and regular sections (Hedberg et al, 2002b) (the two methods corresponded significantly (P=0.009)), validating the results obtained from the TMA.
In addition to alterations of adipocytes, the microvessel density in 4°C WATs and 4°C iBAT was significantly increased, validating the fact that cold exposure could switch to an angiogenic phenotype in the adipose tissue (Xue et al., 2009).
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